詹固
1、个人简介
詹固博士，成都中医药大学高层次引进人才，特聘副教授，四川省特聘专家。2007-2016年于四川大学华西药学院学习并获得理学博士学位。同年赴美国纽约州立大学进行博士后研究，合作导师为张强教授，研究多肽的选择性化学合成。随后加入日本国立理化学研究所进行博士后研究，师从著名化学家侯召民教授。相关科研成果发表在chem. soc. rev., angew. chem. int. ed., j. am. chem. soc., chem. sci., acs catal.等国际顶级学术期刊上，并获得了“2018年日本国立理化学研究所研究奖励奖”、“2019年日本国立理化学研究所理事长感谢状”、“2019年英国皇家化学会obc壁报奖”等个人奖项。目前的主要研究方向为中药相关手性化合物的催化合成、创新药物研发以及不对称催化新方法开发，任frontiers in catalysis杂志副主编、frontiers in chemistry杂志客座编辑、泰国中医药杂志编委。2019年底加入成都中医药大学药学院以来，已获“国家自然科学基金青年项目”、“四川省科技厅应用基础研究项目”、“成都中医药大学引进人才科研启动项目”等资助。
二、个人代表性成果
[1] g. zhan , w. du , y.c. chen, switchable divergent asymmetric synthesis via organocatalysis, chem. soc. rev., 46 (2017) 1675-1692. (中科院一区，if:60.615)
[2] r. qin, f.m. you, q. zhao, x. xie, c. peng, g. zhan*, b. han*, naturally derived indole alkaloids targeting regulated cell death (rcd) for cancer therapy: from molecular mechanisms to potential therapeutic targets, j. hematol oncol., 15 (2022) 133. (中科院一区，if:23.168)
[3] g. zhan, h.l. teng, y. luo, s.j. lou, m. nishiura, z.m. hou*, enantioselective construction of silicon-stereogenic silanes by scandium-catalyzed intermolecular alkene hydrosilylation, angew. chem. int. ed., 57 (2018) 12342-12346. (中科院一区，if:16.823)
[4] g. zhan, m.l. shi, q. he, w.j. lin, q. ouyang, w. du, y.c. chen*, catalyst-controlled switch in chemo- and diastereoselectivities: annulations of morita-baylis-hillman carbonates from isatins, angew. chem. int. ed., 55 (2016) 2147-2151. (中科院一区，if:16.823)
[5] y.h. ma, s.j. lou, g. luo, y. luo, g. zhan, m. nishiura, y. luo, z.m. hou*, b(c6f5)3/amine-catalyzed c(sp)-h silylation of terminal alkynes with hydrosilanes: experimental and theoretical studies, angew. chem. int. ed., 57 (2018) 15222-15226. (中科院一区，if:16.823)
[6] x.f. cong, g. zhan, z.b. mo, m. nishiura, z.m. hou*, diastereodivergent [3 2] annulation of aromatic aldimines with alkenes via c-h activation by half-sandwich rare-earth catalysts, j. am. chem. soc., 142 (2020) 5531-5537. (中科院一区，if:16.383)
[7] h.l. teng, y.h. ma, g. zhan, m. nishiura, z.m. hou*, asymmetric c(sp)-h addition of terminal alkynes to cyclopropenes by a chiral gadolinium catalyst, acs catal., 8 (2018) 4705-4709. (中科院一区，if:13.700)
[8] q.q. luo, z. tian, j. tang, j. wang, y. tian*, c. peng, g. zhan*, b. han*, design and application of chiral bifunctional 4-pyrrolidinopyridines: powerful catalysts for asymmetric cycloaddition of allylic n-ylide, acs catal., 12 (2022) 7221-7232. (中科院一区，if:13.700)
[9] r. zhou, j.s. li, h.w. cheo, r. chua, g. zhan, z.m. hou, j. wu, visible-light-mediated deuteration of silanes with deuterium oxide, chem. sci., 10 (2019) 7340-7344. (中科院一区，if:9.969)
[10] h.j. leng, q. zhao, q. mao, s.j. liu, m.l. luo, r. qin, w. huang*, g. zhan*, nhc-catalysed retro-aldol/aldol cascade reaction enabling solvent-controlled stereodivergent synthesis of spirooxindoles, chin. chem. lett., 32 (2021) 2567-2571. (中科院一区，if:8.455)
[11] x. tang, n. zhang, g. he, c.h. li, w. huang, x.y. wang, g. zhan*, b. han*, unconventional [2 3] cyclization involving [1,4]-sulfonyl transfer to construct polysubstituted fluorazones as inhibitors of indoleamine 2,3-dioxygenase 1, org. lett., 22 (2020) 7909-7914. (中科院一区，if:6.072)
[12] x. tang, y.l. wu, j. jiang, h.y. fang, w.j. zhou, w. huang*, g. zhan*, formal (3 1 1) carboannulation of morita-baylis-hillman carbonates with pyridinium ylides: access to spiro-cyclopentadiene oxindoles, org. lett., 23 (2021) 8937-8941. (中科院一区，if:6.072)
[13] q.w. pang, j. zhou, y.l. wu, w.j. zhou, w.f. zuo, g. zhan*, b. han*, construction of oxo-bridged diazocines via rhodium-catalyzed (4 3) cycloaddition of carbonyl ylides with azoalkenes, org. lett., 24 (2022) 1362-1366. (中科院一区，if:6.072)
[14] m.l. luo, q.m. hou, s.j. liu, q. zhao, r. qin, c. peng, b. han*, g. zhan*, one-step synthesis of hydropyrrolo[3,2-b]indoles via cascade reactions of oxindole-derived nitrones with allenoates, org. lett., 24 (2022) 8493-8497. (中科院一区，if:6.072)
[15] d.a. li, x.h. he, x. tang, y.l. wu, h.l. zhao, g. he, c. peng, b. han*, g. zhan*, organo/silver dual catalytic (3 2)/conia-ene type cyclization: asymmetric synthesis of indane-fused spirocyclopenteneoxindoles, org. lett., 24 (2022) 6197-6201. (中科院一区，if:6.072)
[16] z. tian, j. jiang, z.h. yan, q.q. luo, g. zhan*, w. huang, x. li*, b. han*, catalytic asymmetric [3 2] cycloaddition of pyrazolone-derived mbh carbonate: highly stereoselective construction of the bispiro-[pyrazolone-dihydropyrrole-oxindole] skeleton, chem. commun., 58 (2022) 5363-5366. (中科院一区，if:6.065)
[17] b.h. chen, s.j. liu, q. zhao, q.m. hou, j.l. yuan, g. zhan, q.q. yang*, w. huang*, palladium-catalyzed asymmetric [4 2] annulation of vinyl benzoxazinanones with pyrazolone 4,5-diones to access spirobenzoxazine frameworks, chem. commun., 59 (2023) 1233-1236. (中科院一区，6.065)
[18] r. qin, q. zhao, b. han, h.p. zhu, c. peng, g. zhan*, w. huang*, indole-based small molecules as potential therapeutic agents for the treatment of fibrosis, front. pharmacol., 13 (2022). (中科院二区，if:5.988)
[19] y.y. ai, d.a. li, g. li, h.p. li, x.h. he, x.j. fu, y.t. wang, g. zhan*, b. han*, asymmetric synthesis of spirocyclopentane oxindoles via [2 3] annulation with 2-(2-oxoindolin-3-yl)malononitriles as 1,2-carbon bisnucleophiles, adv. synth. catal., 363 (2021) 3283-3289. (中科院二区，if:5.981)
[20] w.f. zuo, j. zhou, y.l. wu, h.y. fang, x.j. lang, y. li, g. zhan*, b. han*, synthesis of spiro(indoline-2,3 '-hydropyridazine) via an "on-water" [4 2] annulation reaction, org. chem. front., 8 (2021) 922-927. (中科院一区，if:5.456)
[22] j. zhou, c. chen, q.w. pang, w.f. zuo, x. li, g. zhan, q.q. yang*, b. han*, cooperative photoactivation/lewis base catalyzed [4 2] annulations of alpha-diazoketones and ortho-amino mbh carbonates to access dihydroquinolinone frameworks, org. chem. front., 10 (2023) 1034-1041. (中科院一区，if:5.456)
[23] j. tang, z.h. yan, g. zhan*, q.q. yang, y.y. cheng, x. li*, w. huang*, visible-light-mediated sequential wolff rearrangement and staudinger cycloaddition enabling the assembly of spiro-pyrazolone-beta-lactams, org. chem. front., 9 (2022) 4341-4346. (中科院一区，if:5.456)
[24] c.h. li, w.f. zuo, j. zhou, w.j. zhou, m. wang, x. li, g. zhan*, w. huang*, catalytic asymmetric synthesis of 3,4 '-indole-pyrazole derivatives featuring axially chiral bis-pentatomic heteroaryls, org. chem. front., 9 (2022) 1808-1813. (中科院一区，if:5.456)
[25] q. zhao, c. peng, y.-t. wang, g. zhan*, b. han*, recent progress on the construction of axial chirality through transition-metal-catalyzed benzannulation， org. chem. front., 9 (2021) 2772–2785. (中科院一区，if:5.456)
[26] x.h. he, x.j. fu, g. zhan*, n. zhang, x. li, h.p. zhu, c. peng, g. he*, b. han*, organocatalytic asymmetric synthesis of multifunctionalized alpha-carboline-spirooxindole hybrids that suppressed proliferation in colorectal cancer cells, org. chem. front., 9 (2022) 1048-1055. (中科院一区，if:5.456)
[27] g. zhan, m.l. shi, w.j. lin, q. ouyang, w. du, y.c. chen, direct asymmetric aza-vinylogous-type michael additions of nitrones from isatins to nitroalkenes, chemistry-a european journal, 23 (2017) 6286-6289. (中科院二区，if:5.020)
[28] q. mao, q. zhao, m.z. li, r. qin, m.l. luo, j. xue, b.h. chen, h.j. leng, c. peng*, g. zhan*, b. han*, construction of cf3-functionalized fully substituted benzonitriles through rauhut-currier reaction initiated [3 3] benzannulation, j. org. chem., 86 (2021) 14844-14854. (中科院二区，if:4.198)
[29] q. zhao, c. peng, g. zhan*, b. han*, synthesis of polysubstituted arenes through organocatalytic benzannulation, rsc advances, 10 (2020) 40983-41003. (中科院三区，if:4.036)
[30] s.r. he, j. wang, j.f. zheng, q.q. luo, h.j. leng, s.x. zheng, c. peng, b. han*, g. zhan*, organocatalytic (5 1) benzannulation of morita-baylis-hillman carbonates: synthesis of multisubstituted 4-benzylidene pyrazolones, new j. chem., 46 (2022) 11617-11622. (中科院三区，if: 3.925)
[31] g. li, x.h. he, h.p. li, q. zhao, d.a. li, h.p. zhu, y.h. zhang, g. zhan*, w. huang*, design, synthesis, and biological evaluation of tetrahydro-alpha-carbolines as akt1 inhibitors that inhibit colorectal cancer cell proliferation, chemmedchem., 17 (2022). (中科院三区，if:3.540)
[32] h.j. leng, y.t. wang, x.h. he, h.l. xia, p.s. xu, p. xiang, q.q. he, g. zhan*, w. huang*, design and efficient synthesis of rala inhibitors containing the dihydro-alpha-carboline scaffold, chemmedchem., 16 (2021) 851-859. (中科院三区，if:3.540)
[33] m.l. shi, g. zhan, w. du, y.c. chen, direct asymmetric aza-vinylogous mannich reaction of nitrones from isatins and ketimines, acta chim. sin., 75 (2017) 998-1002. (中科院三区，if:2.789)
[34] g. zhan, m.l. shi, q. he, w. du, y.c. chen*, [4 3] cycloadditions with bromo-substituted morita-baylis-hillman adducts of isatins and n-(ortho-chloromethyl)aryl amides, org. lett., 17 (2015) 4750-4753.if: (中科院一区，if:6.072)
[35] m.l. shi, g. zhan, s.l. zhou, w. du, y.c. chen, asymmetric inverse-electron-demand oxa-diels-alder reaction of allylic ketones through dienamine catalysis, org. lett., 18 (2016) 6480-6483. (中科院一区，if:6.072)
[36] y.r. chen, g. zhan, w. du, y.c. chen, regioselective asymmetric formal (3 2) cycloadditions of nitrone ylides from isatins and enals, adv. synth. catal., 358 (2016) 3759-3764. (中科院二区，if:5.981)
[37] w.j. lin, g. zhan, m.l. shi, w. du, y.c. chen, [3 3] formal cycloadditions of nitrones from isatins and azaoxyallyl cations for construction of spirooxindoles, chin. j. chem. 35 (2017) 857-860. (中科院二区，if:5.560)