郭力-mile米乐体育

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中药化学方向

郭力

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一、个人简介

博士,教授,博士生导师,国务院特殊津贴专家,四川省学术和技术带头人,四川省中医药学术和技术带头人,四川省有突出贡献优秀专家。长期从事中药化学成分与中药质量标准化研究,探索和阐明中药药效物质基础,重点围绕川产道地药材附子、川乌、石斛、熊胆粉等品种的化学成分、炮制、配伍、药理活性等多方面研究,对建立其质量控制体系进行了积极探索。研发新药及健康产品10余项,主持多项科研课题,授权专利10余项,出版专著20余部,发表论文百余篇,其中sci论文50余篇,包括biomaterials》、《european journal of medicinal chemistry》、《phytochemical analysis》、《chemical record》等著名期刊;培养硕博研究生50余名。

二、代表性成果(可含承担项目、发表论文、论著、获奖等)

一)项目

1. 国家科技部,国家重点研发项目子课题,2017yfc1701804,高品质道地药材中药材附子规模化种植及精准扶贫示范研究,2018.01-2021-12, 37.5万元,结题,主持

2. 四川省科技厅,四川省科技基础条件平台项目,2019jdpt0032,四川省中药化合物资源共享平台,2019.01-2021.12,12.5万元,结题,主持

3. 国家自然科学基金,区域创新发展联合基金,u19a2010,川产道地药材的道地性研究,2020.01-2023.12247万元,在研,主研

4. 横向课题,熊胆、梅花鹿系列产品研究开发,成都晶博生物科技有限责任公司,2020.07-2022.07,120万元,在研,主持

二)论文:

1. xiao haijun#; guo yiping#; liu hongmei; liu yushi; wang yumin; li changqing; jaroslav císař; david škoda; ivo kuřitka; guo li*; vladimír sedlaříkp*; structure-based design of charge-conversional drug self-delivery systems for better targeted cancer therapy, biomaterials, 2020, 232.

2. li he#; qian su#; lan bai#; meifeng li; juanru liu; xiaomei liu; cunyan zhang; zhongliang jiang; jun he; jianyou shi*; shan huang*; li guo*; recent research progress on natural small molecule bibenzyls and its derivatives in dendrobium species, european journal of medicinal chemistry, 2020, 112530.

3. zhang zhen##; jiang maoyuan#; wei xinyi; shi jingfeng; geng zhao; yang shasah; fu chaomei*; guo li*; rapid discovery of chemical constituents and absorbed components in rat serum after oral administration of fuzi-lizhong pill based on high-throughput hplc-q-tof/ms analysis, chinese medcine, 2019, 14(6): 1-22.

4. liu hongmei; fang chengxin; zhang tingmo; guo li*; ye qiang*; molecular authentication and differentiation of dendrobium species by rdna its region sequence analysis, amb express, 2019, 9(53): 1-9

5. ye qiang; liu hongmei; fang chengxin; liu yushi; liu xiaomei; liu juanru; zhang cunyan; zhang tingmo; peng cheng*; guo li*; cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish, drug and chemical toxicology, 2019: 1-8.

6. zhang xiao; zou, lihua; he yulin; peng cheng; guo li*; xiong liang*. triterpenoid saponins from the buds of lonicera similis. natural product research, 2018, 32: 2282-2290.

7. liu ys, yuan mh, zhang cy, liu hm, liu jr, wei al, ye q, zeng b, li mf, guo yp, guo l*. puerariae lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism. biomed pharmacother. 2021; 134:111121.

8. liu h, yuan m, liu y, guo y, xiao h, guo l*, liu f. self-monitoring and self-delivery of self-assembled fluorescent nanoparticles in cancer therapy. int j nanomedicine. 2021; 16:2487-99.

9. guo y, liu h, xiao h, yuan m, liu y, sedlarik v, chin wc, liu j, guo l*, li c. self-assembled camptothecin derivatives - curcuminoids conjugate for combinatorial chemo-photodynamic therapy to enhance anti-tumor efficacy. j photochem photobiol b. 2021; 215:112124.

10. lei k, yuan m, zhou t, ye q, zeng b, zhou q, wei a, guo l*. research progress in the application of bile acid-drug conjugates: a "trojan horse" strategy. steroids. 2021; 173:108879.

三)获奖:

1. 郭力,参附注射液品质控制与产业化关键技术应用,国家科技部,国家科学技术进步奖,二等奖,2013

2. 郭力,乌头类有毒中药安全性评价模式的建立与示范,中国医疗保健国际交流促进会,华夏医学科技奖,二等奖,2013

3. 郭力,参附注射液的基础、临床与产业化关键问题研究,四川省人民政府,四川省科技进步奖,一等奖,2012

4. 郭力,附子的系统研究与开发应用,四川省人民政府,四川省科技进步奖,一等奖,2010

5. 郭力,病证结合动物模型创制与中药复方有效部位创新中药寻找模式研究,四川省人民政府,四川省科技进步奖,一等奖,2006

终审:药学院管理员
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