陈士林
1、个人简介
陈士林，男，中国医学科学院学部委员，国际欧亚科学院院士。现任成都中医药大学首席教授、中国中医科学院首席研究员、香港浸会大学荣誉教授，兼任世界卫生组织传统医学合作中心主任， cgcm（中药全球化联盟）副主席、中国质量协会中药分会会长等；为教育部“长江学者和创新团队计划”创新团队负责人，曾任中国医学科学院药用植物研究所所长、中国中医科学院中药研究所所长、香港理工大学客座教授等，并在英国皇家植物园丘园接受专业培训、哈佛医学院mclean医院做访问学者等。兼任日本东京药科大学客座教授、美国药典传统中药咨询组委员等。担任apsb，chinese medicine,《药学学报》等刊副主编。获得第二届全国创新争先奖章。
陈士林创建了基于its2的中草药dna条形码鉴定方法体系，完成专著《中国药典中药材dna条形码标准序列》，从基因层面解决中草药物种真伪鉴定的难题，被评为2016中国十大医学进展。通过全基因组解析提出灵芝为首个中药基原药用模式真菌，被nature china 选为中国最佳研究亮点推介；完成并发表人参 、丹参 、赤芝 、菊花 、卷柏 、穿心莲 、紫芝 、紫苏、黄连、红豆杉黄花蒿等全基因组图谱和相关组学研究，成功培育并获批11个中药材新品种证书或良种证书，提出并主编《本草基因组学》学科由科学出版社出版，列为全国高等医药院校规划教材，出版《药用植物分子遗传学》，奠定药用植物分子遗传学基础。完成并编著《中国中药材产地生态适宜性数值区划》，避免中药材盲目引种栽培；
获吴阶平医药创新奖、agilent thought leadership award、诺奖之星等荣誉；获国家科技进步二等奖3项。获国家发明专利和美国专利授权38项，发表论文500余篇，其中sci 论文300余篇，包括国际著名期刊nature plants, nature communications, pnas等，论文被引用3万余次。 入选elsevier高被引中国学者榜单和“终身科学影响力排行榜（1960-2019）”。
二、代表性成果（可含承担项目、发表论文、论著、获奖等）
1.sun s, shen x, li y, li y, wang s, li r, zhang h, shen g, guo b, wei j, xu j, st-pierre b, chen s*, sun c. single-cell rna sequencing provides a high-resolution roadmap for understanding the multicellular compartmentation of specialized metabolism. nature plants. 2023, 9(1):179-190.
2.chen s*, xu j, liu c, zhu y, nelson dr, zhou s, li c, wang l, guo x, sun y, luo h, et. al. genome sequence of the model medicinal mushroom ganoderma lucidum. nature communications. 2012, 3, 913.
3.zhang yj, shen , leng , zhang , chen , shi yh, ning zm, chen sl*. incipient diploidization of the medicinal plant perilla within 10,000 years，nature communications. 2021, 12(1):5508.
4.liu y, wang b, shu s, li z, song c, liu d, niu y, liu j, zhang j, liu h, hu z, huang b, liu x, liu w, jiang l, alami mm, zhou y, ma y, he x, yang y, zhang t, hu h, barker ms, chen s*, wang x, nie j. analysis of the coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. nature communications. 2021, 12(1):3276.
5.chen s*, song j, sun c, xu j, zhu y, verpoorte r, fan tp*. herbal genomics: examining the biology of traditional medicines. science. 2015,347(6219): s27-s29.
6.china plant bol group, li dz, gao lm, li ht, wang h, ge xj, liu jq, chen zd, zhou sl, chen sl, yang jb, fu cx, zeng cx, yan hf, zhu yj, sun ys, chen sy, zhao l, wang k, yang t, duan gw. comparative analysis of a large dataset indicates that internal transcribed spacer (its) should be incorporated into the core barcode for seed plants. pnas. 2011,108:19641-19646.
7.liao b, shen x, xiang l, guo s, chen s, meng y, liang y, ding d, bai j, zhang d, czechowski t, li y, yao h, ma t, howard c, sun c, liu h, liu j, pei j, gao j, wang j, qiu x, huang z, li h, yuan l, wei j, graham i, xu j, zhang b, chen s*. allele-aware chromosome-level genome assembly of artemisia annua reveals the correlation between ads expansion and artemisinin yield. molecular plant. 2022, 5(8):1310-1328.
8.song c, liu y, song a, dong g, zhao h, su w, ramakrishna shyam, wang y, wang s, li t, niu y, jiang j, dong b, xi y, che s, h z, che f, chen shilin*. the chrysanthemum nankingense genome provides insights into the evolution and diversification of chrysanthemum flowers and medicinal traits. molecular plant. 2018, 11(12): 1482-1491.
9.chen x, yang z, xu y, liu z, liu y, dai y, chen s*. progress and prediction in multicomponent quantification of complex systems with practical lc-uv methods. journal of pharmaceutical analysis, 2022.
10.guo m, pang x, xu y, jiang w, liao b, yu j, xu j, song j, chen s*. plastid genome data provide new insights into the phylogeny and evolution of the genus epimedium. journal of advanced research. 2021, 36:175-185.
11.xu j, chu y, liao b, xiao s, yin q, bai r, su h, dong l, li x, qian j, zhang j, zhang y, zhang x, wu m, zhang j, li g, zhang l, chang z, zhang y, jia z, liu z, daniel afreh, ruth nahurira8, zhang l, cheng r, zhu y, zhu g, rao w, zhou c, qiao l, huang z, cheng yung-chi, chen shilin*, panax ginseng genome examination for ginsenoside biosynthesis. gigascience. 2017, 6(11):1-15.
12.chen s*, li z, zhang s, zhou y, xiao x, cui p, xu b, zhao q. kong s,dai y emerging biotechnology applications in natural product and synthetic pharmaceutical analyses. acta pharmaceutica sinica b. 2022, 12(11).
13.xu j, guo s, yin x, li m, su h, liao x, li q, le l, chen s, liao b, hu h, lei j, zhu y, qiu x, luo l, chen j, cheng r, chang z, zhang h, wu nc, guo y, hou d, pei j, gao j, hua y, huang z, chen s*. genomic, transcriptomic, and epigenomic analysis of a medicinal snake, bungarus multicinctus, to provides insights into the origin of elapidae neurotoxins. acta pharmaceutica sinica b. 2022.
14.luo l, jiang j, wang c, fitzgerald m, hu w, zhou y, zhang h, chen s*. analysis on herbal medicines utilized for treatment of covid-19. acta pharmaceutica sinica b. 2020, 10: 1192-1204.
15.luo l, dong l, huang q, ma s, fantke p, li j, jiang j, fitzgerald m, yang j, jia z, zhang j, wang h, dai y, zhu g, xing z, liang y, li m, wei g, song j, wei j, peng c, zhang h, zhang w, wang s, mizuno k, marco a, wu l, xu j, xiong c, chen s*. detection and risk assessments of multi-pesticides in 1771 cultivated herbal medicines by gc/ms-ms and lc/ms-ms. chemosphere. 2021,262:127477.
16.z xu, t xin, dorothea bartels, y li, w gu, h yao, s liu, h yu, x pu, j zhou, j xu, c xi, h lei jing, yuan song, shilin chen*. genome analysis of the ancient tracheophyte selaginella tamariscinareveals evolutionary features relevant to the acquisition of desiccation tolerance. molecular plant. 2018. 11(7):983-994.
17.shilin chen*, pang x, song j, shi l, yao h, han j, leon c. a renaissance in herbal medicine identification: from morphology to dna. biotechnology advances. 2014, 32 (7), 1237-1244.
18.h xu, j song, h luo, y zhang, q li, y zhu, j xu, y li, c song, b wang, w sun, g shen, x zhang, j qian, a ji, z xu, x luo, l he, c li, c sun, h yan, g cui, x li, xi li, j wei, j liu,y wang, a hayward, d nelson, z ning, rj. peters, x qi, s chen*. analysis of the genome sequence of the medicinal plant salvia miltiorrhiza. molecular plant. 2016, 9(6): p949–952.
19.zheng x, an w, yao h, xu j, chen s*. rapid authentification of the poisonous plant gelsemium elegans by combining filter-paper-based dna extraction and rpa-lfd detection. engineering. 2021,7(1):14-16.
20.li x, yang y, henry rj, rossetto m, wang y, shilin chen*. plant dna barcoding: from gene to genome. biological reviews. 2015, 90 (1):157-166.
21.li q, li y, song j*, xu h, xu j, zh y, li x, gao h, dong l, qian j, sun c, shilin chen*. high-accuracy de novo assembly and snp detection of chloroplast genomes using a smrt circular consensus sequencing strategy. new phytologist. 2014, 204 (4): 1041-1049.