师健友-mile米乐体育

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中药化学方向

师健友

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一、  个人简介

       2010年博士毕业于四川大学药物化学专业。2013-2016年跟随导师魏于全院士从事博士后研究。2010年7月至今在电子科技大学附属医院·四川省人民医院任职,现为研究员、教授、硕博士研究生导师,美国北卡罗来纳大学教堂山分校访问学者(2016-2018),曾任四川省药物流行病学专委会委员、四川省预防医学会药物应用安全分委会委员、四川省国际医学交流促进会生物免疫治疗专业委员会委员等,现任世界中医药联合会道地药材多维评价理事、中国化学快报青年编委、中国医学生物技术协会纳米生物技术分会委员,被评为第十三批四川省卫生健康委员会学术与技术带头人、第十二批四川省学术与技术带头人后备人选、第十一批省卫生计生委学术技术带头人后备人选。主要从事小分子药物设计与新药开发工作。作为项目负责人,先后承担国家自然基金项目 2 项,中国博士后科研基金面上项目 1 项,国家中医药管理局临床基地建设项目 1 项,四川省自然科学基金创新研究群体项目1项,四川省科技厅杰出青年基金培育项目 1 项,四川省科技厅青年科技创新研究团队项目1项,成都市科技局应用基础项目 1 项,电子科技大学中央高校基金 1 项课题等。近 5 年,申请国家发明专利 9 项,获得 6项国家发明专利授权,在sttt、jmc、ccl、ejmc 等药学权威期刊杂志上发表多篇相关学术论文,其中第一(含并列)作者及通讯作者50余篇。

二、代表性成果(可含承担项目、发表论文、论著、获奖等)

1.科研项目:

1.1 基于计算机辅助设计和spr发现新颖的skp2抑制剂及其抗肿瘤活性与机制研究,82073311,在研,56万

1.2 个体化药物治疗小分子创新药物四川省青年科技创新研究团队,2022jdtd0025,在研,40万

1.3 结构新颖的lsd1/gsk3β双靶点小分子抑制剂的设计、合成与抗胃癌药理学研究,2021ly021,在研,30万

1.4 基于智能控制算法神经网络模型研究真空冷冻干燥川芎工艺,2021hx026,在研,10万

1.5 基于计算机辅助的hdac/aurora双靶点 抑制剂的设计、合成、活性筛选及机制研究,川干研2022-219,在研,5万

2.发表论文

【1】 lu haiying, zhou qiaodan, he jun, jiang zhongliang, peng cheng*, tong rongsheng*, shi jianyou*, recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials [j], signal transduction and targeted therapy, 5(1), 213, 2020

【2】   peng ting, qi baowen, he jun, ke hengming*, shi jianyou*, advances in the development of phosphodiesterase-4 inhibitors [j], journal of medicinal chemistry, 63(19): 10594-10617, 2020

【3】   qi baowen, zhong ling, he jun, zhang hongjia, li fengqiong, wang ting, zou jing, lin yao-xin, zhang chengchen, guo xiaoqiang, li rui*, shi jianyou*, discovery of inhibitors of aurora/plk targets as anticancer agents [j], journal of medicinal chemistry, 62(17): 7697-7707, 2019

【4】   hou jun, jiang changqing, wen xudong, li chengming, xiong shiqiang, yue tian, long pan*, shi jianyou*, zhang zhen*, acsl4 as a potential target and biomarker for anticancer: from molecular mechanisms to clinical therapeutics [j], frontiers in pharmacology, 13, 949863, 2022

【5】 liang qi, liu maoyu, li jian, tong rongsheng, hu yonghe*, bai lan*, shi jianyou*, nae modulators: a potential therapy for gastric carcinoma [j], european journal of medicinal chemistry, 231, 114156, 2022

【6】   wu xianbo, xu yihua, liang qi, yang xinwei, huang jianli, wang jie, zhang hong*, shi jianyou*, recent advances in dual pi3k/mtor inhibitors for tumour treatment [j], frontiers in pharmacology, 13, 875372, 2022

【7】   xin ren, jianyou shi, ruihuan duan, jun di, chao xue, xiao luo, qing liu, mengyang xia∗, bo lin∗, wu tang∗, construction of high-efficiency cos@nb2o5 heterojunctions accelerating charge transfer for boosting photocatalytic hydrogen evolution [j], chinese chemical letters, 33, 4700-4704, 2022

【8】   zhang zhenzhen, liu xin, zhao liyun, zhou yaru, shi jianyou*, chen weini*, li jinqi*, a review on the treatment of multiple myeloma with small molecular agents in the past five years [j], european journal of medicinal chemistry, 229, 114053, 2022

【9】   liang qi, wang juelan, zhao liyun, hou jun*, hu yonghe*, shi jianyou*, recent advances of dual fgfr inhibitors as a novel therapy for cancer [j], european journal of medicinal chemistry, 214, 113205, 2021

【10】 wang ting, xu kaiju, zhao liyun, tong rongsheng*, xiong liang*, shi jianyou*, recent research and development of ndm-1 inhibitors [j], european journal of medicinal chemistry, 223, 113667, 2021

【11】 zhao jing, hu gang, huang yi, huang yingchun*, wei xin*, shi jianyou*, polysaccharide conjugate vaccine: a kind of vaccine with great development potential [j], chinese chemical letters, 32(4): 1331-1340, 2021

【12】 du xingkai, li jian, luo xiaojiao, li rong, li feng, zhang yiwen, shi jianyou*, he jun*, structure-activity relationships of wee1 inhibitors: a review [j], european journal of medicinal chemistry, 203, 112524, 2020

【13】 he li, su qian, bai lan, li meifeng, liu juanru, liu xiaomei, zhang cunyan, jiang zhongliang, he jun, shi jianyou*, huang shan*, guo li*, recent research progress on natural small molecule bibenzyls and its derivatives in dendrobium species [j], european journal of medicinal chemistry, 204, 112530, 2020

【14】 wang ting, wang yujue, liu li, jiang zhongliang, li xingxing, tong rongsheng, he jun*, shi jianyou*, research progress on sirtuins family members and cell senescence [j], european journal of medicinal chemistry, 193, 112207, 2020

【15】 yuan ting, qi baowen, jiang zhongliang, dong wenjuan, zhong lei, bai lan, tong rongsheng, yu jiying*, shi jianyou*, dual flt3 inhibitors: against the drug resistance of acute myeloid leukemia in recent decade [j], european journal of medicinal chemistry, 178468-483, 2019

【16】 zhou yanping, jiang zhongliang, lu haiying, xu zhuyu, tong rongsheng, shi jianyou*, jia guiqing*, recent advances of natural polyphenols activators for keap1-nrf2 signaling pathway [j], chemistry & biodiversity, 16(11): 2019

3.获奖

3.1 2020年入选第一批“浣花英才计划”学科骨干项目

3.2 四川省卫生健康委员会第五期委(局)直属单位高层次人才专题研修班优秀学员。


终审:药学院管理员
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