彭伟
一、个人简介
彭伟，博士、博士后、副教授、硕士生导师，现工作于成都中医药大学药学院。2020，2022年全球前2%科学家（药学与药理学，斯坦福大学）、世界中医药学会联合会翻译专业委员会常务理事、世界中医药学会联合会中药调剂委员会理事。frontiers in pharmacology 副主编、中医杂志（英文版）青年编委、tmr integrative medicine编委、future integrative medicine编委、中草药（英文版）青年编委、西南医科大学学报青年编委、广州医科大学学报青年编委。medicinal research reviews、pharmacological research、journal of natural products, phytomedicine, journal of ethnopharmacology, frontiers in pharmacology, phytotherapy research等杂志审稿人。
主要研究方向为中药炮制与制剂、中药及复方药效物质基础。主持中国博士后基金一等资助、四川省自然科学基金等部省级课题3项、厅局级课题3项、主研国家级/省部级课题8项。h-index 30（web of science），发表学术论文100余篇，以第一或通讯作者在pharmacological research、journal of advanced research、phytomedicine等sci杂志发表论文70余篇，被nature metabolism等杂志正面引用3000余次，单篇最高被引190次，esi高被引论文9篇。获得授权发明专利3项，适用新型专利2项，软件著作权1项。
二、代表性成果
(1)bingke bai, chang liu, chengzhong zhang, xuhui he, hongrui wang, wei peng*, chengjian zheng*. trichoderma species from plant and soil: an excellent resource for biosynthesis of terpenoids with versatile bioactivities. journal of advanced research, 2022, doi: 10.1016/j.jare.2022.09.010.
(2)ruolan li, huxinyue duan, qi liang, yongliang huang, lingyu wang, qing zhang, chunjie wu*, shuqin liu*, wei peng*. targeting matrix metalloproteases: a promising strategy for herbal medicines to treat rheumatoid arthritis. frontiers in immunology, 2022, 13: 1046810.
(3)ruolan li, lingyu wang, huxinyue duan, qing zhang, xiaohui guo*, chunjie wu*, wei peng*. regulation of mitochondrial dysfunction induced cell apoptosis is a potential therapeutic strategy for herbal medicine to treat neurodegenerative diseases. frontiers in pharmacology, 2022, 13:937289.
(4)wei peng, nan li, ercheng jiang, chao zhang, yongliang huang, ling tan, ruyan chen, chunjie wu*, qinwan huang*. a review of traditional and current processing methods used to decrease the toxicity of the rhizome of pinellia ternata in traditional chinese medicine. journal of ethnopharmacology, 2022,299:115696.
(5)qing zhang, die qian, dandan tang, jia liu, linyu wang, wenwen chen, chunjie wu*, wei peng*. glabridin from glycyrrhiza glabra possesses a therapeutic role against keloid via attenuating pi3k/akt and transforming growth factor-β1/smad signaling pathways. journal of agricultural and food chemistry, 2022,70(35):10782-10793.
(6)wenqing li#, wenhao liu#, die qian, jia liu, shiqiong zhou, lei zhang, wei peng*, li su*, hong zhang*. traditional chinese medicine: an important source for discovering candidate agents against hepatic fibrosis. frontiers in pharmacology, 2022, 13, 962525.
(7)mengmeng zhang, daneng wei, lin he, dan wang, li wang, dandan tang, rong zhao, xun ye, chunjie wu*, wei peng*. application of response surface methodology (rsm) for optimization of the supercritical co2 extract of oil from zanthoxylum bungeanum pericarp: yield, composition and gastric protective effect. food chemistry:x, 2022, 15, 100391.
(8)qing zhang, wenwen chen, xue sun, die qian, dandan tang, lilin zhang, meiyan li, linyu wang, chunjie wu*, wei peng*. the versatile emodin: a natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers. international journal of biological sciences, 2022, 18(8): 3498-3527.
(9)ruolan li, lingyu wang, shuqin liu, huxinyue duan, qing zhang, ting zhang, wei peng*, yongliang huang*, chunjie wu*. natural flavonoids derived from fruits are potential agents against atherosclerosis. frontiers in nutrition, 2022, 9: 862277.
(10)wei peng#, yunhui chen#,*, steve tumilty, lizhou liu, ling luo, haiyan yin, yongmei xie. paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of ca2 and ros homeostasis. current opinion in pharmacology, 2022, 62:97-102.
(11)wenqing li#, wenhao liu#, die qian, jia liu, shiqiong zhou, lei zhang, wei peng*, li su*, hong zhang*. traditional chinese medicine: an important source for discovering candidate agents against hepatic fibrosis. frontiers in pharmacology, 2022, 13, 962525.
(12)ting zhang, qing zhang, wei zheng, ting tao, ruolan li, liyu wang, wei peng*, chunjie wu*. fructus zanthoxyli extract improves glycolipid metabolism disorder of type 2 diabetes mellitus via activation of ampk/pi3k/akt pathway: network pharmacology and experimental validation. journal of integrative medicine, 2022, 20(6):543-560
(13)qing zhang, jia liu, xinyue duanhu, ruolan li, wei peng⁎, chunjie wu⁎. activation of nrf2/ho-1 signaling: an important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress. journal of advanced research,2021,34:43-63
(14)gang gong, yuli shen, haiyue lan, jinmei jin, pei an, lijun zhang, lili chen, wei peng*, xin luan*, hong zhang*. the cyr61 is a potential target for rotundifuran, a natural labdane-type diterpene from vitex trifolia l., to trigger apoptosis of cervical cancer cells. oxidative medicine and cellular longevity, 2021, 2021, 6677687.
(15)huxinyue duan#, qing zhang#, jia liu, ruolan li, dan wang, wei peng*, chunjie wu*. suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis. pharmacological research 2021, 168: 105599
(16)yu long, qiyue yang, yan xiang, yulu zhang, jinyan wan, songyu liu, nan li*, wei peng*. nose to brain drug delivery - a promising strategy for active components from herbal medicine for treating cerebral ischemia reperfusion. pharmacological research 2020, 159: 104795
(17)shujun wei, qing zhang, yongjing xiang, lanyu peng, wei peng*, qiang ren*, yongxiang gao*. guizhi-shaoyao-zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating nf‐κb signalling to suppress osteoclastogenesis. pharmaceutical biology 2021, 59(1): 262-274.
(18)yulu zhang, yu long, shuang yu, dan li, ming yang, yongmei guan, dingkun zhang, jinyan wan, songyu liu, ai shi, nan li*, wei peng*. natural volatile oils derived from herbal medicines: a promising therapy way for treating depressive disorder. pharmacological research 2021, 164: 105376.
(19)yu long, yan xiang, songyu liu, yulu zhang, jinyan wan, qiyue yang, mingquan cui, zhimin ci, nan li*, wei peng*. baicalin liposome alleviates lipopolysaccharide-induced acute lung injury in mice via inhibiting tlr4/jnk/erk/nf-κb pathway. mediators of inflammation 2020, 2020:8414062.
(20)mengmeng zhang, rong zhao, dan wang, li wang, qing zhang, shujun wei, feng lu, wei peng*, chunjie wu*. ginger (zingiber officinale rosc.) and its bioactive components are potential resources for health beneficial agents. phytotherapy research 2021, 35(2), 711-742.
(21)ruolan li#, qing zhang#, jia liu, jiayi sun, liying he, huxinyue duan, wei peng*, chun-jie wu*. hydroxy-α-sanshool possesses protective potentials on h2o2 stimulated pc12 cells by suppression of oxidative stress induced apoptosis through regulation of pi3k/akt signal pathway. oxidative medicine and cellular longevity 2020, 2020: 3481758.
(22)wei peng#, qianling ming#, xin zhai, qing zhang, khalid rahman, sijia wu, luping qin*, ting han*. polysaccharide fraction extracted from endophytic fungus trichoderma atroviride d16 has an influence on the proteomics profile of the salvia miltiorrhiza hairy roots. biomolecules 2019, 9: 415.
(23)qing zhang#, wei peng#, shujun wei, daneng wei, ruolan li, jia liu, lanyu peng, shuang yang, yongxiang gao*, chunjie wu*, xufeng pu*. guizhi-shaoyao-zhimu decoction possesses anti-arthritic effects on type ii collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts. biomedicine & pharmacotherapy 2019, 118: 109367.
(24)wei peng#, huan du#, guangli liu, qing zhang, tingting kuang, zhang wang*, gang fan*. antistress effects of san-huang-xie-xin decoction on restraint-stressed mice revealed by 1h nmr-based metabolomics and biochemistry analysis. oxidative medicine and cellular longevity 2019, 2019: 5897675.
(25)qing zhang, jia liu, mengmeng zhang, shujun wei, ruolan li, yongxiang gao, wei peng*, chunjie wu*. apoptosis induction of fibroblast-like synoviocytes is an important molecular mechanism for herbal medicine and its active components to treat rheumatoid arthritis. biomolecules 2019, 9: 795.
(26)mengmeng zhang#, mingguo xie#, daneng wei, li wang, meibian hu, qing zhang, zuxing he, wei peng*, chunjie wu*. hydroxy-α-sanshool isolated from zanthoxylum bungeanum attenuates learning and memory impairments in scopolamine-treated mice. food & function 2019, 10:7315-7324.
(27)li wang, wenxiang fan, mengmeng zhang, qing zhang, lin li, jiaolong wang, lei zhu, daneng wei, wei peng*, chunjie wu*. anti-obesity, regulation of lipid metabolism, and attenuation liver oxidative stress effects of hydroxy-α-sanshool isolated from zanthoxylum bungeanum in high-fat diet-induced hyperlipidemic rats. oxidative medicine and cellular longevity 2019, 2019: 5852494.
(28)jin wang, lin wang, guan-hua lou, hai-rong zeng, ju hu, qin-wan huang*, wei peng*, xiang-bo yang. coptidis rhizoma: a review of its traditional uses, botany, phytochemistry, pharmacology, toxicology. pharmaceutical biology 2019, 57(1):193-225.
(29)wei peng#, hui shen#, bing lin, ping han, changhui li, qiaoyan zhang, bingzhu ye, khalid rahman, hailiang xin, luping qin*, ting han*. docking study and antiosteoporosis effects of a dibenzylbutane lignan isolated from litsea cubeba targeting cathepsin k and mek1. medicinal chemistry research 2018, 27(9): 2062-2070.
(30)mengmeng zhang, jiaolong wang, lei zhu, tao li, weidong jiang, juan zhou, wei peng*, chunjie wu*. zanthoxylum bungeanum maxim. (rutaceae): a systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology. international journal of molecular sciences, 2017, 18(10): 2172.